USMLE Step 1 Exam Guide 2025: Format, Syllabus, Score Requirements, and Preparation Tips

Written by

Salma Firdaus

Reviewed by

Dr. Rini Sharma
USMLE Step 1 Exam Guide
Created On : Aug 11, 2025 Updated On : Aug 11, 2025 5 min read

Key Takeaways

  • Understand what the USMLE Step 1 is all about.
  • Find out who all needs to take the Step One exam.
  • Discover the exam syllabus and pattern
  • Learn about the steps to register for the exam.
  • Explore the best preparation strategy for a successful USMLE Step 1 attempt.

Did you know that the US is among the highest-paying destinations for doctors? You can earn anything from USD 200,000 to USD 350,000 annually. That is more than 2.5 Cr in INR. The States present a gold standard for medical practice and medical registration. 

Once you are registered to practice in the USA, you are put on the world map.

But where do you begin this journey?  Well, it all starts with the USMLE exams, or the United States Medical Licensing Exam. 

Today, we will dissect everything there is to know about Step 1 of the USMLE. From the exam syllabus to preparation tips. This guide is your one-stop resource to understand USMLE Step 1.

Let’s get into it.

The United States Medical Licensing Exam

The USMLE Step 1 is the first major milestone for medical students dreaming of practicing in the U.S. It is also known as USMLE Part 1.

It is the first of three exams in the United States Medical Licensing Examination series. It's designed to test your understanding of the basic sciences, essential to the practice of medicine.

Think of it as your foundation check-up. Are your medical basics solid? If yes, Step 1 is your chance to shine.

Exam Format- 2025 Edition

Step 1 is a one-day computer-based exam. The exam duration is around 8 hours. It's divided into 7 blocks, each lasting 60 minutes.

  • Each block can have up to 40 questions.
  • In total, there’ll be 280 MCQs.
  • You get 45 minutes of break time.
  • There is also an optional 15-minute tutorial.

If you’re a first-time test taker, use the tutorial. It will help you to get acquainted with the format.

What does the USMLE Step 1 test?

The USMLE exams are not just about memorization. The Step 1 exam tests how well you can apply basic science in real-world clinical scenarios.

Core SubjectsInterdisciplinary Topics
Biochemistry & Nutrition
Physiology 
Microbiology 
Pathology 
Pharmacology 
Behavioural Sciences 
Genetics 
Immunology 
Histology and Cell Biology 
Gross Anatomy & Embryology
Epidemiology
Medical Ethics
Biostatistics
Patient Safety
USMLE Step 1 Topic Distribution
Based on Data from the USMLE Official website

 

The USMLE Step One exam is more about understanding than memorizing. 

What is the Scoring System for USMLE Step 1?

Since 2022, the Step 1 result has been displayed as Pass/Fail.

This means:

  • No more 3-digit scores.
  • A passing score is at or above 196.
  • You can retake the exam if you fail.

Competitive residency programs review your transcript. If you pass on your first try, it adds weight to your CV.

Who Should Take Step 1

Step 1 is the first USMLE step for International Medical Graduates or IMGs.

Usually, in the USA, second or third-year medical students take it after completing basic sciences. 

IMGs should be enrolled in a medical college listed under the World Directory of Medical Schools (WDOMS).

Also, your school must meet ECFMG certification requirements.

Registration Process for USMLE Step 1

Step 1: Eligibility Check

For U.S. and Canadian Students:

Be enrolled in or a graduate of a medical school accredited by the:

  • LCME (for MD programs) or 
  • COCA (for DO programs)

For International Students:

  • Your medical school must be listed in the WDOMS.
  • You must be outside the U.S. or Canada.
  • You will apply through ECFMG- Educational Commission for Foreign Medical Graduates.

Step 2: Register for a USMLE ID

For IMGs:

  • Go to the ECFMG portal.
  • Create an ECFMG account and obtain your USMLE/ECFMG Identification Number (USMLE ID).
  • This number will be used for all future USMLE exams.
ECFMG Register for a USMLE ID

For U.S./Canadian Students:

  • Register through the NBME website.
  • Your medical school might register you directly via the NBME Registration Portal.

You’ll need the following documents:

  • A valid email address
  • Passport-sized photo
  • A valid passport
  • Government-issued ID

Step 3: Apply for an Eligibility Period

  • Choose a 3-month eligibility window 
  • You can take the test during this period
  • Schedule your exam.

Pick a window that gives you enough time to prepare.

Step 4: Pay the Exam Fees

  • U.S./Canadian Students: USD 670 
  • IMGs: USD 1020 (INR 87,720)
  • Fees for International testing centers: USD 205 (INR 17,630)

Pay online via credit card during the application process.

Step 5: Submit Certification Documents

  • Complete Form 186. This is the Certification of Identification Form.
  • Notarize online using NotaryCam.
  • Upload your medical school documents.

Once submitted and verified, ECFMG will approve your application. Your Scheduling Permit will be emailed to you within a few weeks.

Step 6: Schedule Your Exam on Prometric

Once you receive your Scheduling Permit, go to the Prometric website.
  • Click on “Schedule My Test
  • Select USMLE as your exam
  • Choose your preferred test center and available date
  • Confirm the appointment and print the confirmation

Required Documents Checklist

DocumentPurpose
Passport-size photoFor ID and profile verification
Valid Passport/IDRequired for Prometric test entry
Medical School Enrollment ProofRequired by ECFMG/NBME
Form 186 (For IMGs)Certifies your identity
Exam Fee ReceiptPayment confirmation
Scheduling PermitNeeded to book and attend the exam

What Happens After Applying?

  • After scheduling, you can reschedule (with a fee) if needed.
  • On exam day, arrive early.
  • Bring your Scheduling Permit and a valid ID to the test center.
  • Results are sent via email in about 3 to 4 weeks.

Timeline Overview

StepApprox. Time Required
Create Account1 day
Document Submission1 to 2 weeks (if all correct)
Application Approval2 to 4 weeks
Scheduling & ExamDepends on your window
Results3 to 4 weeks post-exam

Final Tips

  • Apply 2 to 3 months before your desired exam date.
  • Keep scanned copies of all documents.
  • Use only the official websites: 
  • ECFMG
  • NBME
  • Prometric
  • Don’t forget to practice with the USMLE sample tutorial before exam day.

Preparation Tips: How to Crush Step One

Start Early, Stay Consistent

Most students prep for 3-6 months. But the key is to be consistent with your preparation.

Top Resources for Step 1

  • First Aid for USMLE Step 1 
  • UWorld for the question bank
  • Pathoma for pathology
  • Sketchy for microbiology and pharma

Study Plan Example

  1. Months 1- 2: Learn & revise with First Aid, watch Pathoma.
  2. Months 3 - 4: Start UWorld and Sketchy. Also, start with Anki.
  3. Months 5 - 6: Take practice tests and identify weak areas. Revise as much as you can. 

Also Read:  USMLE Step 1 Practice Questions & Exams 

Common Mistakes to Avoid

  • Rushing through UWorld
  • Ignoring review
  • Memorizing without understanding

Practice Exams & Self-Assessment

Use NBME practice tests and UWorld self-assessments to know your readiness. Some popular ones:

  • NBME Forms 25–27
  • UWSA1 & UWSA2
  • NBME Free 120, which is the official sample questions

If you’re consistently scoring above 65-70%, you’re likely exam-ready. 

The best way to prepare is by joining a USMLE Preparation Course. The structured format and routine assessment will help with an organized preparation plan. 

Test Day Tips

  • Sleep well the night before.
  • Carry a valid ID and confirmation email.
  • Pack snacks and water.
  • Use break time wisely.

Don’t panic if one block feels tough. Each block is scored separately.

Visual mnemonics and patient-based cases are very helpful.

How to Stay Motivated?

  • Join a study group or online forum.
  • Set weekly goals.
  • Reward yourself after long sessions.

Final Thoughts: Make Step 1 Your Stepping Stone

USMLE Step 1 is a challenge, yes. But it’s also a huge opportunity to prove your knowledge and dedication.

You’re not alone in this journey. Thousands of students crack it every year. With the right strategy, resources, and mindset, you can too.

And Academically is here to guide every step of the way. With us, you’ll find:

  • Successful alumni
  • Expert teacher
  • AI-Backed Mock Exams
  • Personalized class
  • Recorded and Live Sessions
  • Document and Resume Help

And so much more. Connect today and explore all your options.

Your future in the U.S. healthcare system begins here.

FAQs

Q- What is USMLE Step 1?

Ans- USMLE Step 1 is the first exam in the United States Medical Licensing Examination series. It tests your basic medical science knowledge and its application in clinical scenarios.

Q- Can I retake Step 1 to improve my score?

Ans- No. Since it’s now Pass/Fail, retakes are only allowed if you fail.

Q- Is Step 1 harder than Step 2 CK?

Ans- Both exams have different focuses. Step 1 is more theory, while Step 2 CK is a clinical exam. Many students find Step 1 tougher.

Q- How long are Step 1 results valid?

Ans- The results don’t expire. But recency matters for residency programs.

Q- What are the pass marks for USMLE Step 1?

Ans- The passing score is 196 or above. But you will get the result simply as Pass/Fail.

Q- How long is the Step 1 exam?

Ans- The exam lasts around 8 hours. It is split into 7 one-hour blocks. Each block can have up to 40 questions.

Q- How many times can I take Step 1?

Ans- You can attempt Step 1 up to four times. But only three times in 12 months.

Q- How far in advance should I register for Step 1?

Ans- It’s best to apply 3 to 6 months before your planned test date. This can help to secure your preferred test center.

Q- Can I reschedule Step 1?

Ans- Yes. Rescheduling fees may apply. It depends on how close is your exam date.

Q- How soon will I get my Step 1 results?

Ans- Results are available within 3 to 4 weeks. You will receive them via email and the NBME/ECFMG portal.

Q- Are breaks allowed during the exam?

Ans- Yes. You get 45 minutes of break time. You can split this time between blocks.

Q- Is there negative marking in Step 1?

Ans- No. Only correct answers add to your score. So you can attempt all questions without fear of losing marks.

Salma Firdaus
Salma Firdaus
about the author

Salma Firdaus is a pharmacy graduate from Jamia Hamdard with three years of research experience and a knack for academic writing. At Academically, she turns complex scientific concepts into clear, engaging content. Driven by a passion to connect education with real-world careers, she aims to make learning easier, more meaningful, and genuinely enjoyable for the readers.

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